The Pieters Laboratory—News
November 08, 2022, Biozentrum
CONTROL OF CELL POPULATION SIZES: WHEN IS ENOUGH ENOUGH?
The team led by Prof. Jean Pieters at the Biozentrum of the University of Basel has uncovered a cell-intrinsic mechanism, that controls the appropriate number of T cells in the organism and thus ensures that the immune system functions properly. This mechanism has also been found in slime moulds, suggesting that this regulation of cell density is evolutionarily conserved. See here for More.
December 21, 2021, Biozentrum
T CELLS: NO TIME TO DIE
They are at the forefront in the fight against viruses, bacteria, and malignant cells: the T cells of our immune system. But the older we get, the fewer of them our body produces. Thus, how long we remain healthy also depends on how long the T cells survive. Researchers led by Prof. Jean Pieters of the Biozentrum, University of Basel, have now uncovered a previously unknown signaling pathway essential for T cell viability. See more.
January 14, 2019, Biozentrum
ENGINEERED T CELLS PROMOTE LONG-TERM ORGAN TRANSPLANT ACCEPTANCE
Organ transplant rejection is a major problem in transplantation medicine. Suppressing the immune system to prevent organ rejection, however, opens the door to life threatening infections. A team of researchers led by Prof. Jean Pieters at the Biozentrum of the University of Basel has now discovered a molecular approach preventing rejection of the transplanted graft while simultaneously maintaining the ability to fight against infections. See here for more.